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Over time, self-medicating in this way can become habitual and co-occur with a mental health disorder. Stopping use is an essential step for treating the physical and depressive symptoms and cognitive impairments caused by ketamine. One case report suggested a glutamate release inhibitor called Lamotrigine to reduce ketamine cravings and depression, which are the most common problems reported by chronic ketamine users. Like other substance abuse treatments, behavioral therapies and support groups may provide further treatment assistance for ketamine addiction. To learn more about the treatment process, read our Ketamine rehabilitation guide, which provides a comprehensive resource for starting this process.
Dosing can be challenging to gauge, and a person could be using the wrong drug altogether, leading to a dangerous overdose. Since the drug is usually found as a powder, it is often sniffed, but most of these powders are mixed with other drugs. It may be mixed with something relatively harmless like talcum powder or sugar, or it could be combined with something more dangerous like acetaminophen or drain cleaner. Ketamine also causes individuals to have no memory of events that happen while they are under its influence. Due to this effect and its ability to sedate and incapacitate, some people use it as a date-rape drug. Perpetrators who use it in this manner may slip it into a beverage of the person they wish to victimize.
Tablets and capsules are packed in small containers, powder in baggies, and liquid in vials. Ketamine is snorted or pressed into tablets in powder form, combined with other drugs like methylenedioxymethamphetamine (MDMA), known as ecstasy. This combination is popular at parties, as it amplifies the hallucinogenic and euphoric effects, increasing the risk of overdose and adverse side effects. Recognizing the above symptoms can help you determine if you or a loved one needs help with ketamine misuse. However, it is important to remember that only a mental health professional can make a diagnosis, and it is best to seek a professional assessment.
The safest way to get help for ketamine abuse is to visit an addiction treatment center that uses detox and therapy to treat symptoms. Since ketamine is designed as a sedative, it is very likely for users to experience intense confusion and delirium when the initial peak effects or “high” dissipates. These individuals may also experience muscle weakness, anxiety, and feelings of hopelessness and helplessness. They may also experience numbness, impaired vision, and severe confusion that often leads to aggressive behavior, amnesia, and delirium.
Even if you've had positive experiences, a slight increase in dosage can be the difference between a good time and a dangerous situation. By following your doctor's instructions carefully and avoiding any misuse of ketamine, you can benefit from this medication without the risk of addiction. According to the 2013 National Survey on Drug Use and Health in the United States, an estimated 2.3 million people aged 12 or older used ketamine in their lifetimes, with 203,000 users in 2013. Ketamine has a short-lived high and tolerance to the drug builds up quickly, requiring users to keep increasing quantities as they chase the initial high. Inpatient rehabs are centers where you ketamine addiction live at the clinic for a set period of time—typically between 30 days and 90 days.
It wasn’t until 1990—nearly 30 years after ketamine’s creation—that researchers under Phil Skolnick, Ph.D., D.Sc., at the National Institute of Diabetes and Digestive and Kidney Diseases made a breakthrough. The team uncovered a clue in N-methyl-D-aspartate (NMDA), the brain’s receptor for the neurotransmitter glutamate. By exposing mice to inescapable stressful events that produced signs similar to depression, researchers found that antagonists, or drugs that block NMDA could alcoholism reduce those symptoms. Ketamine, in small doses, is being explored as an option to decrease depressive symptoms in cases where they might not respond to other treatments.
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